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Glycerol to Succinic Acid process
 

Glycerol to Succinic Acid process

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The primary innovation is a batch fermentation technology that, with the aid of an adapted microorganism, produces good yields of succinic acid from crude glycerol. In addition, the team has developed ...

The primary innovation is a batch fermentation technology that, with the aid of an adapted microorganism, produces good yields of succinic acid from crude glycerol. In addition, the team has developed predictive computational models of this bioprocess that have been experimentally validated. The models have allowed the team to determine optimal operating conditions and policies yielding excellent experimental results.

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    Glycerol to Succinic Acid process Glycerol to Succinic Acid process Document Transcript

    • THE UNIVERSITY OF MANCHESTER INTELLECTUAL PROPER Succinic acid production from biorefinery glycerolBACKGROUNDSuccinic acid is an important industrial chemical intermediate for a Dr Theodoropoulos with Professor Colin Webb at the 2011 IChemEwide range of dyes, perfumes, lacquers, photochemicals, resins, Award ceremonyplasticisers and pharmaceuticals. Conventionally, it is produced bycatalytic hydrogenation of maleic acid, a petroleum-derived feedstock.It is identified as one of the leading ‘building block’ chemicals for non-petroleum based production by the US Department of Energy.An award-winning research team at the University of Manchester,under the direction of Dr. Constantinos Theodoropoulos and Prof. ColinWebb, has developed an alternative process, which provides abiochemical route to produce succinic acid from glycerol, a plentifullow-value waste product of biodiesel production.THE TECHNOLOGYThe primary innovation is a batch fermentation technology that, with the aid of an adaptedmicroorganism, produces good yields of succinic acid from crude glycerol. In addition, the teamhas developed predictive computational models of this bioprocess that have been experimentallyvalidated. The models have allowed the team to determine optimal operating conditions andpolicies yielding excellent experimental results.KEY BENEFITS  Turnkey technology to enable transformation of single-process biorefineries to next generation multi-process, integrated biorefineries.  Improvement of sustainability and cost-effectiveness of biodiesel production through the valorisation of main by-product.  Use of low-value waste product from biodiesel production to deliver a low-cost low-energy route to a high-value platform chemical.  Ability to utilise glycerol in its crude form without the need for a purification step.  Carbon benefits from replacement of petroleum-derived feedstock. UMIP - REPUTATION AND VALUE THROUGH INTELLECTUAL PROPERTY®
    • THE UNIVERSITY OF MANCHESTER INTELLECTUAL PROPERAPPLICATIONSThe technology is likely to be of interest to the biorefinery industry, industrial producers and usersof succinic acid and the biodiesel industry.INTELLECTUAL PROPERTY Schematic of bio-reactorThe process is protected by international patent filing(PCT/GB2012/050887) and the specific strain of microorganism,(Actinobacillus Succinogenes) has been lodged under the BudapestTreaty. There is additional know-how associated with the modellingand optimisation process.OPPORTUNITYFollowing a UMIP-funded Proof of Principle project, development iscurrently at around Technology Readiness Level 4/5, withexperimental results achieved at 150 litre. The next major technicalmilestone will be scale-up to between 1000 – 5000 litre, for whichwe will be seeking e.g. TSB funding or investment or a combinationof both.UMIP has recently commissioned the National Non-Food Crops Centre(NNFCC), based in York, to undertake a market review and iscurrently seeking partners interested in commercialising thetechnology.It is expected that the transfer of technology would occur by appropriate licensing agreements.CONTACTSimon Clarke Licensing Manager, UMIP, Core Technology Facility, 46 Grafton Street, Manchester M13 9NT: Simon.Clarke@umip.com : +44 (0) 161 306 8510 © UMIP September 2012 UMIP - REPUTATION AND VALUE THROUGH INTELLECTUAL PROPERTY®