Lipoprotein and cholesterol

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  • 1. LIPOPROTEIN AND CHOLESTEROL Angel Das 1 year MBBS Student
  • 2. LIPOPROTEIN Lipid Lipoprotein Protein
  • 3. Structure of lipoprotein INTEGRAL APOPROTEINS CHOLESTEROL ESTERS MONOLAYER OF PHOSPHOLIPID AND CHOLESTERLOL CORE TRIGLYCERIDES PERIPHERAL APOPROTEINS
  • 4. APOPROTEINS Protein component of lipoprotein Promote transport and uptake of lipids Act as ligand Activation of enzymes
  • 5. APOPROTEINS A B • A-l • A-ll • B-48 • B-100 • A-I Liver& intestine • A-II Liver • B-48 • B-100 C E • C-l • C-ll • C-lll Intestine Liver • All Liver • Liver
  • 6. LIPOPROTEINS Lipoprotein Apoproteins Chylomicron A,B,C,E VLDL B,C,E LDL B HDL A,C,D, E
  • 7. CLASSIFICATION Based on density by ultracentrifugation i. Chylomicrons ii. Very Low Density Lipoprotein iii.Intermediate Density Lipoprotein iv.Low Density Lipoprotein v. High Density Lipoprotein
  • 8. COMPOSITION AND SIZE OF LIPOPROTEIN
  • 9. FUNCTIONS OF LIPOPROTEINS CHYLOMICRONS transport Triglycerides from intestine to adipose tissues for storage. VLDL carries triglycerols from liver to peripheral tissues.
  • 10. LDL transports cholesterol from liver to peripheral tissues. HDL transports cholesterol from peripheral tissues to liver “Reverse Cholesterol Transport”
  • 11. CLINICAL SIGNIFICANCE HYPERLIPIDEMIAS elevated lipid fraction cholesterol/TAG Frederickson’s Classification  Type l  Type ll A  Type ll B  Type lll  Type lV  Type V
  • 12. Type Lipoprotein Metabolic fraction Defect elevated Type ll A (Primary LDL Familial Hypercholesterolemia) LDL receptor defect Type ll B Hyperlipoproteinemia LDL & VLDL Apo B Type lV Familial endogenous Type VLDL Overproduction of VLDL
  • 13.  HYPOLIPOPROTEINEMIAS i. Abetalipoproteinemia microsomal triglyceride transfer protein is defective LDL & VLDL decreases ii. Hypo alpha lipoproteinemia HDL level decreases iii. Tangier Disease absence of ATP binding Cassette Transporter 1, involved in transport of cellular cholesterol to HDL
  • 14.  ATHEROSCLEROSIS • Deposition of LDL cholesterol in arterial wall, occurs due to damage of endothelium
  • 15. CHOLESTEROL Physical Properties white crystalline solid substance soluble in ether,chloroform etc. amphipathic in nature abundantly present in nervous tissue •Have
  • 16. STRUCTURE OF CHOLESTEROL
  • 17. FUNCTIONS OF CHOLESTEROL 1. Major structural constituent of the cell membranes and lipoproteins 2. Precursor for Steroid hormones a. Progesterons b. Glucocorticoids c. Mineralocorticoids d. Androgens & Estrogens 3. Formation of Bile acids and bile salts. 4. Synthesis of Vitamin D