Lipoprotein and cholesterol

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Lipoprotein and cholesterol

  1. 1. LIPOPROTEIN AND CHOLESTEROL Angel Das 1 year MBBS Student
  2. 2. LIPOPROTEIN Lipid Lipoprotein Protein
  3. 3. Structure of lipoprotein INTEGRAL APOPROTEINS CHOLESTEROL ESTERS MONOLAYER OF PHOSPHOLIPID AND CHOLESTERLOL CORE TRIGLYCERIDES PERIPHERAL APOPROTEINS
  4. 4. APOPROTEINS Protein component of lipoprotein Promote transport and uptake of lipids Act as ligand Activation of enzymes
  5. 5. APOPROTEINS A B • A-l • A-ll • B-48 • B-100 • A-I Liver& intestine • A-II Liver • B-48 • B-100 C E • C-l • C-ll • C-lll Intestine Liver • All Liver • Liver
  6. 6. LIPOPROTEINS Lipoprotein Apoproteins Chylomicron A,B,C,E VLDL B,C,E LDL B HDL A,C,D, E
  7. 7. CLASSIFICATION Based on density by ultracentrifugation i. Chylomicrons ii. Very Low Density Lipoprotein iii.Intermediate Density Lipoprotein iv.Low Density Lipoprotein v. High Density Lipoprotein
  8. 8. COMPOSITION AND SIZE OF LIPOPROTEIN
  9. 9. FUNCTIONS OF LIPOPROTEINS CHYLOMICRONS transport Triglycerides from intestine to adipose tissues for storage. VLDL carries triglycerols from liver to peripheral tissues.
  10. 10. LDL transports cholesterol from liver to peripheral tissues. HDL transports cholesterol from peripheral tissues to liver “Reverse Cholesterol Transport”
  11. 11. CLINICAL SIGNIFICANCE HYPERLIPIDEMIAS elevated lipid fraction cholesterol/TAG Frederickson’s Classification  Type l  Type ll A  Type ll B  Type lll  Type lV  Type V
  12. 12. Type Lipoprotein Metabolic fraction Defect elevated Type ll A (Primary LDL Familial Hypercholesterolemia) LDL receptor defect Type ll B Hyperlipoproteinemia LDL & VLDL Apo B Type lV Familial endogenous Type VLDL Overproduction of VLDL
  13. 13.  HYPOLIPOPROTEINEMIAS i. Abetalipoproteinemia microsomal triglyceride transfer protein is defective LDL & VLDL decreases ii. Hypo alpha lipoproteinemia HDL level decreases iii. Tangier Disease absence of ATP binding Cassette Transporter 1, involved in transport of cellular cholesterol to HDL
  14. 14.  ATHEROSCLEROSIS • Deposition of LDL cholesterol in arterial wall, occurs due to damage of endothelium
  15. 15. CHOLESTEROL Physical Properties white crystalline solid substance soluble in ether,chloroform etc. amphipathic in nature abundantly present in nervous tissue •Have
  16. 16. STRUCTURE OF CHOLESTEROL
  17. 17. FUNCTIONS OF CHOLESTEROL 1. Major structural constituent of the cell membranes and lipoproteins 2. Precursor for Steroid hormones a. Progesterons b. Glucocorticoids c. Mineralocorticoids d. Androgens & Estrogens 3. Formation of Bile acids and bile salts. 4. Synthesis of Vitamin D

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