Medical tourism in Croatia: Stem cell therapies

1 CROATIAN MEDICAL TOURISM Center for Regenerative Medicine “ME-DENT” Dental polyclinic Aesthetic surgery Regenerative medicine Center for Regenerative Medicine “ME-DENT” www.croatianmedicaltourism.com

CROATIAN MEDICAL TOURISM 2 Center for Regenerative Medicine “ME-DENT” Center for Regenerative Medicine “ME-DENT” www.croatianmedicaltourism.com

3 CROATIAN MEDICAL TOURISM Center for Regenerative Medicine “ME-DENT” CONTENT ABOUT US THE FOUNDER DR ENES HODZIC DENTAL POLYCLINIC AESTHETIC SURGERY REGENERATIVE MEDICINE www.croatianmedicaltourism.com

CROATIAN MEDICAL TOURISM 4 Center for Regenerative Medicine “ME-DENT” Center for Regenerative Medicine “ME-DENT” The Center for Regenerative Medicine “ME-DENT” is a privatly-funded organization involved in Dentistry, Aesthetic Surgery and Advanced Regenerative Medicine Technologies and research related to biological medicines. ME-DENT is a modern-purpose built medical practice, situated in the heart of Rovinj, (Istria), with a Dental Polyclinc branch in Metković, southern Dalmatia, the Republic of Croatia. “ME-DENT” is promoting a comfortable, relaxing clinical environment, boasting the latest high-tech equipment. This enables us to provide updated quality care for our patients. The founder of the Center for Regenerative Medicine “ME-DENT” is Dr. Enes Hodzic Dr. Hodzic was born on June 2nd 1944 in Mostar, Bosnia and Herzegovina. He graduated from the Dentistry Faculty in Belgrade in 1971 and ended his specialisation in maxillofacial surgery in 1985 at the Military Medical Academy of Belgrade where he also practiced in plastic surgery. In 1986 he was trained in Norway (Oslo, Rikshospitalet University Hospital) at the plastic surgery ward. After returning from Oslo he worked in the Mostar’s hospital as maxillofacial surgeon. Following the war in Bosnia & Herzegovina (1992-1995) he opened his Private Dental Policlynic dr. Hodžić in Metković and it’s branch in Rovinj. In 2009 he founded The Center for Regenerative Medicine “ME-DENT” in Rovinj, in the Republic of Croatia. Qualitiy Team - a key for success The doctors at the CENTER FOR REGENERATIVE MEDICINE “ME-DENT” are highly trained specialists. They were trained in Norwey (Oslo, Rikshospitalet University Hospital), and Japan (Nagasaki, Nagasaki University). All our physicians are multi-lingual (English, Italian, German, Japanese, French and Russian) At the CENTER FOR REGENERATIVE MEDICINE “ME-DENT” you will find the top professional level as in other best rated facilities around the world. www.croatianmedicaltourism.com

5 CROATIAN MEDICAL TOURISM Center for Regenerative Medicine “ME-DENT” Enes Hodzic, DDS He was born on June 2, 1944 in Mostar, Bosnia and Herzegovina. He graduated Dentistry Faculty in Belgrade in 1971. He ended specialisation in maxillofacial surgery in 1985 at Military Medical Academy of Belgrade where he also got experience in plastic surgery. In 1986 he was trained in Norway (Oslo, Rikshospitalet University Hospital) on plastic surgery ward. After returning from Oslo he worked in Mostar’s hospital as maxillofacial surgeon. After the War in Bosnia and Herzegovina (1992-1995) he opened Private Dental Policlynic dr. Hodzic in Metkovic and it’s subsidiary in Rovinj. In 2009 he founded Center for Regenerative Medicine “ME-DENT” in Rovinj, Republic of Croatia. Education: 1965 – 1971 – Dentistry Faculty, Belgrade University, Yugoslavia. 1981- 1985 - Specialisation in Maxillofacial Surgery, Military Medical Academy, Belgrade, Yugoslavia. 1986 – 1986 – Plastic Surgery Department, Rikshospitalet University Hospital, Oslo, Norway. Professional experience: 1986 – 1991 – Department of Maxillofacial Surgery, Mostar Municipal Hospital, Mostar, Yugoslavia. 1991 – 1995 – period without employment (Civil War in former Yugoslavia) 1995 – june 2009 – Private Dental Policlynic dr. Hodzic., Metkovic, Croatia June 2009 – present time - Dental Polyclinic Dr. Hodzic & Center for Regenerative Medicine ”ME-DENT”, Rovinj, Croatia. Additional information: 2004 – present time Master Opinion Teacher for Sky Implant System, Germany; Master Opinion Teacher for Straumann Implant System, Switzerland. 2006 – present time - Member of ITI (international team of implantologists). Dental Polyclinic Diagnosis Correct diagnosis requires the knowledge of a doctor and the precise technology of today’s most advanced instruments that assist doctors in establishing good diagnosis. Digital Planmeca ortopan produced in Finland is one of those instruments. With the help of this instrument a doctor is able to assess the quality and density of the bone, blood vessell capacity, see the processes in the roots, determin the right place for an implant, the position of existing implants and so on. Today’s modern dentistry leaves nothing to chance. www.croatianmedicaltourism.com

CROATIAN MEDICAL TOURISM 6 Center for Regenerative Medicine “ME-DENT” Conservative Dentistry Conservative Dentistry is the branch of dentistry which means the complete restoration, functionally and aesthetically, of the patient’s original tooth. That includes dental fillings (new fillings and replacement), root canal treatment, crowns, bridges, veneers, inlays and onlays. Our dental clinic offers all types of conservative dental procedures, as well as a number of services in cosmetic dentistry: tooth fillings root canal treatment dental inlays and onlays dental veneers dental crowns dental bridges Prosthetics Dental prostheses: crowns, bridges or dentures. A bridge, also known as a fixed partial denture, is a dental restoration used to replace a missing tooth by joining permanently to adjacent teeth or dental implants. We provide all kinds of prosthesis with teeth of Your choice: Wissil prosthesis / skeleton prosthesis, with knuckle belts Prosthesis on “smile” crowns Reduced prosthesis on rail Solo crowns or bridges with material of patients choice with suggestion from a doctor, on natural teeth or implants Cemented bridges or removable bridges (every few months) Oral surgery Oral and maxillofacial surgery corrects a wide spectrum of diseases, injuries and defects in the head, neck, face, jaws, hard and soft tissues of the oral and maxillofacial region. It is a recognized international surgical specialty. We provide: Resections (removal of tooth-root abscess) www.croatianmedicaltourism.com

7 CROATIAN MEDICAL TOURISM Center for Regenerative Medicine “ME-DENT” Parodontale operations Alveolectomy of the molar Alveolectomy of the remaining root Hemisection of the molar Surgical treatment of light wounds on facial soft tissue, scarrs and skin moles Jaw cyst removal Vestibuloplastic / tuberoplastic Frenulectomy Odontotomy Sinus plastic Sinus lift Excision of the parulis (a subperiosteal abscess of the gum) Resorption operation with building in of aloplastic materials (fisiograft, emdogain...) Oral implantology A dental implant is an artificial tooth root used in dentistry to support restorations that resemble a tooth or group of teeth. Virtually all dental implants placed today are root-form endosseous implants and are placed within the bone. Dental Reconstructive Technologies/Regenerative Dentistry An ideal goal of oral-craniofacial dental reconstructive therapy is to establish treatment modalities that predictably restore functional tissues. One major area of focus has been in the area of dental materials with marked improvements in the design of materials used to restore teeth/periodontium/bone lost as a consequence of disease or disorders. More than 85% of the global population requires repair or replacement of a craniofacial structure. These defects range from simple tooth decay to radical oncologic craniofacial resection. Advanced technologies by using tissues repair cells and growth factors represent a very interesting field for craniofacial tissues regeneration. They represent a potential key component in autologos graft for craniofacial tissues regeneration. Recent progress in the studies of molecular basis of tooth development, adult stem cell biology, and regeneration are providing fundamental knowledge for the utilization of human craniofacial tissues regeneration. Our Center has introduced a new technology “Autologous bone marrow derived mononuclear cells combined with Bone Replacement Materials (Xenografts) in Advanced Maxillary and Mandibular Atrophy” - a safe effective method for replacing missing bone and adding mass to existing bone for dental implants. www.croatianmedicaltourism.com

CROATIAN MEDICAL TOURISM 8 Center for Regenerative Medicine “ME-DENT” Orthodontics It’s never too early or too late to think about orthodontics. Orthodontic treatment can be successful at any age. Whether you are a child, adolescent or adult, we are committed to help you to achieve the smile you have always wanted! At first visit we will take an OPG, listen to your needs and concerns, examine your teeth and jaws, discuss the treatment options and the treatment process. If treatment is indicated, orthodontic records, study models, photographs and radiographs, will be done. Periodontology Periodontology, or Periodontics, is the branch of dentistry which studies supporting structures of teeth, and diseases and conditions that affect them. The supporting tissues are known as the periodontium. Periodontium includes the gingiva (gums), alveolar bone, cementum, and the periodontal ligament. The word comes from the Greek words peri meaning around and odons meaning tooth. Literally taken, it means study of that which is “around the tooth”. Periodontal diseases are those diseases that affect one or more of the periodontal tissues: 1. alveolar bone 2. periodontal ligament 3. cementum 4. gingiva While many different diseases affect the tooth-supporting structures, plaque-induced inflammatory lesions make up the vast majority of periodontal diseases and have traditionally been divided into two categories: 1. gingivitis or 2. periodontitis. While in some sites or individuals, gingivitis never progresses to periodontitis, data indicates that gingivitis always precedes periodontitis. Aesthetic Surgery A complete range of cosmetic, plastic, and reconstructive surgical procedures Dr. Enes Hodzic and his staff are dedicated to providing you with the finest possible medical services in a state-of-the-art surgical facility. A complete range of cosmetic, plastic, and reconstructive surgical procedures are available including the most advanced techniques in skin care and hair care. www.croatianmedicaltourism.com

9 CROATIAN MEDICAL TOURISM Center for Regenerative Medicine “ME-DENT” Our team performs all surgical procedures and provides your postoperative care with the support of a highly trained staff for surgical assistance, nursing care, anesthesia and recovery. The Center for Regenerative Medicine “ME-DENT” provides a full range of services from the latest aesthetic surgery procedures to the most advanced techniques in skin care and hair care. Aesthetic/Cosmetic Plastic Surgery - Facial correction - Blepharoplasty - Brow Lift (Forehead Lift) - Chin and Cheek - Implants - Eyelid Tuck ( Forehead Lift ) - Facelift - Lip augmentation - Nose Job - Rhinoplasty - Dermatology - Skin Care Breast Surgery Procedures - Breast Lift (Mastopexie) - Breast Reduction - Pectoral Implants (Men) - Breast Augmentation Other Cosmetic Procedures: - Brachioplasty (Arm Lift) - Liposuction - Lipoplasty - Mesotherapy Cellulite - Hair Removal - Crioesklerosis (remove varicose veins) - Treatments for stretch marks - Tattoo Removal - Tummy Tuck, Abdominoplastic - Operations for weight loss - General Plastic or Cosmetic Surgery Advanced Technologies for Breast Augmentation An advanced procedure for breast augmentation based on regenerative medicine and involves the collection of stem cells from adipose tissue and the injection of those cells, together with adipose tissue, to allow semi-permanent maintenance of breast conditions after injection. Celution™ Breast Augmentation (transplantation of adipose tissue-derived stem cells) is a procedure for breast augmentation based on regenerative medicine and involves the collection of stem cells from adipose tissue and the injection of those cells, together with adipose tissue, to allow semi-permanent maintenance of breast conditions after injection. www.croatianmedicaltourism.com

CROATIAN MEDICAL TOURISM 10 Center for Regenerative Medicine “ME-DENT” Using the patient’s own adipose tissue, the procedure represents a highly safe treatment with no concern for rejection. With a proven track record in liposuction and injection technology, Center for Regenerative Medicine “ME-DENT” soon will provide Celution™ Breast Augmentation (transplantation of adipose tissue-derived stem cells), a cutting-edge procedure for breast augmentation on the basis of regenerative medicine. ME-DENT Skin Regeneration Therapy Our clinics have introduced a new technology for extraction of platelet-rich plasma containing autologous white blood cells that has a PRP enrichment rate of about 6- to 10- fold (about three to five times higher than that for conventional one) and contains white blood cells, which are not contained in conventional PRP. The therapy is found to have much greater efficacy in rejuvenating the skin, eliminating wrinkles, and reducing irregularities from acne marks compared with conventional therapy. INDICATIONS In conventional cosmetic medicine, hyaluronic acid and collagen are commonly injected. Now that * PRP Skin Regeneration Therapy is available, and the patient’s own blood may be used to improve all symptoms. * PRP - platelet-rich plasma PRP Skin Regeneration Therapy, a type of regenerative medicine with the patient’s own blood, uses components called platelets in the blood to rejuvenate the skin.Based on an innate wound- healing ability, the therapy is performed by injecting components collected from the blood and is associated with no risk of allergy or infections.The safe therapy has been studied and applied in a variety of fields. It is indicated for a wide variety of conditions; it is used for the treatment of trauma and burn in the department of plastic surgery and also used as an adjunct to implant therapy in the department of dentistry. Addition of a certain ratio of growth factors to PRP allows treatment of deep nasolabial grooves, which are difficult to treat with conventional platelet therapy, and prolongs the duration of efficacy. Maximizing the regenerative potential of PRP, which has the effect of potentiating your innate natural healing power and tissue reorganization potential, PRP Skin Regeneration Therapy is the cutting-edge, anti-aging procedure. The therapy uses the patient’s own blood and thus poses no risk of allergy. It requires only one injection, and repeated clinical visits are not necessary. Regenerative Medicine Center For Regenerative Medicine “ME-DENT” is a cutting edge medical clinic that uses advanced regenerative technologies to treat chronic diseases for which there are inadequate standard therapies. www.croatianmedicaltourism.com

11 CROATIAN MEDICAL TOURISM Center for Regenerative Medicine “ME-DENT” The using of autologous tissues repair cells as they have no ethical or moral issues and pose no possibility for rejection since they come from the patient’s own body. Regenerative Medicine is the process of creating living, functional tissues to repair or replace tissue or organ function lost due to age, disease, damage, or congenital defects. This field holds the promise of regenerating damaged tissues and organs in the body by stimulating previously irreparable organs to heal themselves. Regenerative medicine also empowers scientists to grow tissues and organs in the laboratory and safely implant them when the body cannot heal itself. Cell technologies – Medicine of 21st century “All diseases begin at cell level” proclaimed the famous German scientist Rudolf Virchov in the 19th. Century. The 21st. Century is a century of biomedicine, cell biology and molecular medicine. It is a century of cells. Pluripotent stem cells offer the possibility of a renewable source of replacement cells and tissues to treat a myriad of diseases, conditions, and disabilities including Parkinson”s a disease and Alzheimer”s disease, spinal cord injury, stroke, burns, heart disease, diabetes, osteoarthritis and rheumatoid arthritis. Stem cell research offers enormous potential for major advances in clinical therapy. Stem cells could be used to replace missing or damaged cells in important diseases. Today, donated organs and tissues are often used to replace those that are diseased or destroyed. Unfortunately, the number of people needing a transplant far exceeds the number of organs available for transplantation. The healing potential of stem cells Another potential application of stem cells is making cells and tissues for medical therapies. Today, donated organs and tissues are often used to replace those that are diseased or destroyed. Unfortunately, the number of people needing a transplant far exceeds the number of organs available for transplantation. Pluripotent stem cells offer the possibility of a renewable source of replacement cells and tissues to treat a myriad of diseases, conditions, and disabilities the total number for today is approximately 150. The risks associated with autologous tissues repair cells therapy are low. They are no different from the risks normally associated with surgical procedures. The entire procedure is performed in compliance with the principles of “Good Manufacturing Practice” and in accordance with the latest technological and medical standards. The therapy involves the use of the patient’s own cells, so the risk of rejection – as there would be in a cell or organ transplant procedure – is almost nil. www.croatianmedicaltourism.com

CROATIAN MEDICAL TOURISM 12 Center for Regenerative Medicine “ME-DENT” Stem Cells Treatment Treat a myriad of diseases, conditions, and disabilities Autologous tissue repair cells offer the possibility of a renewable source of replacement cells and tissues to treat a myriad of diseases, conditions, and disabilities the total number for today is approximately 150. OUR CURRENT RESEARCH AND CLINICAL ACTIVITIES by using autologous tissue repair cells: Dentistry: parodontosis parodontitis periodontitis bone regeneration after teeth extraction cysts gum recession implanthology Angiology and Cardiology: critical limb ischemia endarteritis obliterates trophical ulcers cardiomyopathies Diabetes: diabetic foot ulcers Liver disorders: liver failure and metabolic disorders Wound healing (Aesthetic/Plastic Surgery and Cosmetology): skin - ulcers burns X-ray lessions www.croatianmedicaltourism.com

13 CROATIAN MEDICAL TOURISM Center for Regenerative Medicine “ME-DENT” Neurological disorders: Parkinson’s disease Alzheimer’s disease multiple sclerosis spinal cord injury stroke amyotrophic lateral sclerosis Orthopedics and traumatology: joint trauma osteogenesis imperfecta (Brittle bone disease) chondrodysplasias osteoarthritis, arthrosis,osteoarthrosis non-healing fractures Urine and reproductive systems: chronic prostatitis sexual disfunction Ageing: * increased energy levels over-all feeling of well-being rejuvenation * The goal of this treatment is: 1. Body protection of acute and chronic ischemic injuries in the central and the peripheral nervous system, cardiovascular system and renal tissue. 2. To get the enhancing effects on body composition, muscle strength, and cardiac and pulmonary functions. “Please, contact us to request more information about Center for Regenerative Medicine “ME-DENT”” www.croatianmedicaltourism.com

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Medical tourism in Croatia: Stem cell therapies

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