Medical Tourism in Croatia - Me-dent clinical cases


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Center For Regenerative Medicine ME-DENT is a cutting edge medical clinic that uses advanced regenerative technologies to treat chronic diseases for which there are inadequate standard therapies.
The using of autologous tissues repair cells as they have no ethical or moral issues and pose no possibility for rejection since they come from the patient's own body.

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Medical Tourism in Croatia - Me-dent clinical cases

  1. 1. Autologous Bone Marrow Derived Mononuclear Cells combined with Bone Replacement Materials* in Craniofacial Tissues Regeneration* Bio-Oss®, Ossceram nano®, Cerabone®-Granulate, OSferion® “ME-DENT” The Center for Regenerative Medicine Rovinj, Croatia
  2. 2. Bone marrow contains cells, called Autologous Bone Marrow DerivedMononuclear Cells that have the potential to induce bone tissue when they areprovided the biological direction to do so. Accordingly, bone marrow has been usedin different ways to augment new bone growth in a variety of medical proceduressuch as repair of severe fractures, and void filling of large bone defects. Inducingnew bone tissue in jawbones with minimal residual ridge or basal bone by bonegrafting has become an accepted procedure to increase bone thickness enough toallow placement of dental implants to replace lost teeth.
  3. 3. In our procedures we used onlybone marrow autologous (patient’sown) cells.This way is absolutely safe for thepatient because there are not anyimmunological conflicts. Moreover, in contrast to majority of clinical researchers we have used a mononuclear cells fraction of the bone marrow because an associated work of stem cells and other cells contained in the fraction gives better expected result.
  4. 4. Our Center has introduced a new technology "Autologous bone marrow derived mononuclearcells combined with Bone Replacement Materials (BRM) in Advanced Maxillary andMandibular Atrophy" - a safe effective method for replacing missing bone and adding mass toexisting bone for dental implants. Mixing of Bone Marrow Mononuclear Cells with Bone Replacement MaterialsBone Marrow Mononuclear Cells Bone Replacement Materials
  5. 5. The model of natural bone regeneration by bone marrow derived mononuclear cells combined with BRM* 1 2 31. Clot stabilization facilitated by Bone Marrow Mononuclear Cells + BRM interconnecting macro and micropores.2. Revascularization, migration of osteoblasts (purple) and in-growth of woven bone (yellow) is enhanced by Bone Marrow Mononuclear Cells + BRM scaffolding.3. Lamellar bone and Bone Marrow Mononuclear Cells + BRM are successfully integrated after approximately six months. BRM is included in the natural physiologic remodeling process (osteoclasts - Blue).
  6. 6. IntroductionReplacing missing bone or adding mass to existing bone isoften essential to the success of a dental implant.A large variety of graft materials have been used for maxillaryand mandibular atrophy.To date there has been no graft material which can beregarded as completely satisfactory.Our experience with autologous bone marrow derivedmononuclear cells combined with Bone ReplacementMaterials (BRM) for augmentation of the extremely atrophiedmaxilla and mandible is presented.
  7. 7. Advanced Diagnostic for Maxillary and Mandibular Atrophy Planmeca ProMax 3D concept is an intelligent and multipurpose X-ray unit series designed to obtain complete information on patient anatomy. The unit provide digital panoramic, cephalometric, 3D CBVT* imaging, and 3D photo, as well as advanced imaging software tools to comply with every possible need in dental radiology.* Cone Beam Volumetric Tomography
  8. 8. Autologous Bone Marrow from patients used as a source forMononuclear Cells.Bone Marrow Mononuclear separated byCell Separation System SEPAX S-100 (Biosafe Group SA, Switzerland). Autologus Bone Marrow in plastic bagBone Marrow exfusion Bone Marrow Mononuclear Bone Marrow Cells separation Mononuclear Cells
  9. 9. Date: 10 October 2009Patient : D. P., 56 y. o., maleDiagnose: Advanced Maxillary and Mandibular Atrophy, bone resorption,parodontosis, gum recession.
  10. 10. Window preparationand sinus membraneelevation
  11. 11. Implant placement
  12. 12. Sinus filled by BRMcombined withautologous bonemarrow derivedmononuclear cells
  13. 13. Gum stitching
  14. 14. BeforeHealing periodin 1 month.Formation ofnew bonecan be observed.The augmentation material is fullyintegrated into the hard tissue.
  15. 15. BeforeHealing periodin 5 months.Completeosteoconductiveintegration ofthe bone subtitutematerial in themature bone isachieved.
  16. 16. Healing periodin 5 months.Completeosteoconductiveintegration ofthe bone subtitutematerial in the maturebone is achieved.
  17. 17. BeforeHealing period In 7 months
  18. 18. Date 29 January 2010Patient : S. L., 46 y. o., femaleDiagnose: Advanced Maxillary and Mandibular Atrophy,bone resorption, parodontosis, gum recession.
  19. 19. Advanced Maxillary Atrophy
  20. 20. Window preparation and sinus membrane elevation
  21. 21. JASON® MEMBRANE(pericardium collagen membrane)
  22. 22. Gum stitching
  23. 23. Healing periods29.01.201005.08.201010.08.2010
  24. 24. Advanced Maxillary Atrophy 30.01.2011 - in 1 year
  25. 25. Date of procedure: 25 November 2010Diagnose: Advanced Maxillary Atrophy, bone resorption, Parodontosis,gum recession. 19.07.2011 08.06.2011 27