Marks’ Basic Medical Biochemistry: A Clinical Approach, 2nd Edition
• Chapter 1: Metabolic Fuels and Dietary Components
• ...
Fuel Metabolism
I
n order to survive, humans must meet two basic metabolic requirements: we
must be able to synthesize eve...
2
In the following section, we will provide an overview of various types of dietary
components and examples of the pathway...
Essential Nutrients
Fuels
Carbohydrates
Fats
Proteins
Required Components
Essential amino acids
Essential fatty acids
Vita...
4 SECTION ONE / FUEL METABOLISM
Energy production
Carbohydrate
Lipid
Protein
Energy utilization
Biosynthesis
Detoxificatio...
In discussions of metabolism and nutrition, energy is often expressed in units of
calories. “Calorie” in this context real...
D. Alcohol
Many people used to believe that alcohol (ethanol, in the context of the diet) has no
caloric content. In fact,...
In biochemistry and nutrition, the
standard reference is often the
70-kg (154-lb) man. This standard
probably was chosen b...
A. Resting Metabolic Rate
The resting metabolic rate (RMR) is a measure of the energy required to maintain
life: the funct...
What are reasonable estimates for
Ivan Applebod’s and Ann O’Rexia’s
daily energy expenditure?
more active during the weeke...
BMI equals:
Weight/height2
(kg/m2
)
or
Weight (lbs) ϫ 704
height2
(in2
)
Where the height is measured without shoes
and th...
and we lose weight. Conversely, if we eat more food than we require for our
energy needs, the excess fuel is stored (mainl...
of carbohydrate to another. However, health problems are associated with the com-
plete elimination of carbohydrate from t...
its amino acids are released into the pool of free amino acids in the body. The
amino acids from dietary proteins also ent...
14 SECTION ONE / FUEL METABOLISM
Table 1.7. VITAMINS a
Dietary
Reference
Intakes (DRI) Consequences
Females (F) of Deficie...
15CHAPTER 1 / METABOLIC FUELS AND DIETARY COMPONENTS
riboflavin is 0.9 mg/day for males between 9 and 13 years of age, 1.3...
Folate is found in fruits and vegeta-
bles: citrus fruits (e.g., oranges),
green leafy vegetables (e.g.,
spinach and brocc...
Cholesterol is obtained from the
diet and synthesized in most cells
of the body. It is a component of
cell membranes and t...
The high intake of sodium and
chloride (in table salt) of the aver-
age American diet appears to be
related to the develop...
The prevalence of obesity in the
U.S. population is increasing. In
1962, 12.8% of the population had
a BMI equal to or gre...
UL does not mean that most individuals who consume more than the UL will suffer
adverse health effects, but that the risk ...
4. The RDA is
(A) the average amount of a nutrient required each day to maintain normal function in 50% of the U.S. popula...
T H E W A I T I N G R O O M
Ivan Applebod returned to his doctor for a second visit. His initial
efforts to lose weight ha...
23CHAPTER 2 / THE FED OR ABSORPTIVE STATE
The body can make fatty acids
from a caloric excess of carbohy-
drate and protei...
24 SECTION ONE / FUEL METABOLISM
A. Carbohydrates
Dietary carbohydrates are converted to monosaccharides. Starch, a polyme...
25CHAPTER 2 / THE FED OR ABSORPTIVE STATE
In the liver and most other tissues,
glucose, fats, and other fuels are oxi-
diz...
and the electron transport chain) occur principally in mitochondria. Glucose, in con-
trast, generates ATP from anaerobic ...
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