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  • 1. MULTIPLE CONGENITAL OCULARANOMALIES IN ICELANDICHORSES By Mareli Ots
  • 2. MULTIPLE CONGENITAL OCULARANOMALIES (MCOA) A hereditary eye defect. First described in Silver colored Rocky Mountain horses. Is caused by the mutation which contains the gene and the mutation that is associated with the Silver coat color (PMEL 17).
  • 3. THE AIM OF THE RESEARCH Ocular defects are caused by the mutation which is restricted to horses who are related to the Rocky Mountain Horse breed. Scientists examined another horse breed (the Icelandic horse) to disprove that. Icelandic horse is historically divergent from Rocky Mountain horses.
  • 4. AnIcelandichorse withthe Silvercoatcolour.
  • 5. RESULTS 24 Islandic horses were examined. 4 of them had the MCOA-phenotype and they were homozygous for the PMEL17 mutation. 14 horses were heterozygous for the PMEL17 mutation and they had the Cyst-phenotype. Three horses were genotyped as PMEL17 heterozygotes but cysts or other forms of anomalies were unable to detect.
  • 6. IRIDAL ABNORMALITIES AND CATARACTS IN THEMCOA-PHENOTYPE
  • 7. CONCLUSION New facts about the syndrome. The syndrome is segregating with the PMEL17 mutation in the Icelandic Horse population. Important in breeding decisions. MCOA syndrome is present in breeds that are more ancient and not closely related to the Rocky Mountain Horse breed.
  • 8. REFERENCES BMC Veterinary Research. 2011. “Multiple congenital ocular anomalies in Icelandic horses”. Available at http://www.biomedcentral.com/1746- 6148/7/21#B1
  • 9. THANK YOU FOR YOUR ATTENTION!