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Organs Immune System 1

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    soy judith te agradesco las presentaciones
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  • 1. THE ORGANS OF THE IMMUNE SYSTEM
  • 2.  
  • 3. Lymphocytes
  • 4.  
  • 5. Lymphocytes
  • 6. SOURCE OF LYMPHOCYTES Fetus Primary Lymphoid Organs Secondary Lymphoid Organs Adult
  • 7. SOURCE OF LYMPHOCYTES
  • 8.  
  • 9. SOURCE OF LYMPHOCYTES
  • 10. HUMAN THYMUS
  • 11. PRIMARY LYMPHOID ORGANS THYMUS (T cell maturation) (> lymphocytes) (< lymphocytes)
  • 12. The functional thymus consists of two cell populations; the stromal cells and the thymocytes. The stromal cells include (1) the subcapsular epithelial cells; (2) the cortical epithelial cells; (3) the medullary epithelial cells; (4) macrophages; and (5) dendritic cells of bone marrow origin. (From Kierszenbaum AL: Histology and cell biology: an introduction to pathology, St Louis, 2002, Mosby.)
  • 13. MHC-dependiente
  • 14. Effects of Adult Thymectomy on Immune Response
  • 15. CHICKEN THYMUS AND BURSA OF FABRICIUS
  • 16.  
  • 17. BURSA OF FABRICIUS (B cell maturation) follicle lumen Cortex (lymphocytes, M Ø, plasma cells) medulla
  • 18. PEYER’S PATCHES Group I (90% Ileum ) Ruminants, Pigs, Horses, Dogs, Humans. Group II Illeum/Jejunum) Rabbits, Rodents.
  • 19. When stimulated by antigen, immunoglobulin A (IgA)-producing B cells are produced in inductive sites, such as the Peyer’s patches.
  • 20. The role of M cells as antigen-processing cells in the intestinal wall. Antigen that enters enterocytes is usually rapidly degraded in lysosomes. Antigen that enters M cells is not degraded. It may be presented directly to intraepithelial lymphocytes within the M. Yersinia, M. tuberculosis, Listeria, reovirus , Salmonella.
  • 21. Structure of the two different types of Peyer’s patch (PP) in sheep. A, An ileal PP at age 8 weeks. B, A PP from the jejunum, also at 8 weeks. Original magnification ×32. (From Reynolds JD, Morris B: Eur J Immunol 13:631, 1983.)
  • 22. SECONDARY LYMPHOID ORGANS LYMPH NODE
  • 23. SECONDARY LYMPHOID ORGANS LYMPH NODE
  • 24. (B cells) (stimulated) (T cells) (unstimulated) (B cells, macrophages, plasma cells) SECONDARY LYMPHOID ORGANS LYMPH NODE
  • 25. SECONDARY LYMPHOID ORGANS LYMPH NODE secondary follicle primary follicle medulla subcapsular sinus dendritic cells
  • 26. Circulation of Lymphocytes
  • 27.  
  • 28. HIGH ENDOTHELIAL VENULES
  • 29.  
  • 30. HIGH ENDOTHELIAL VENULES
  • 31.  
  • 32. HIGH ENDOTHELIAL VENULES
  • 33.  
  • 34.  
  • 35. RP WP B cell follicle PLS Marginal Zone SPLEEN
  • 36.  
  • 37. SPLEEN
  • 38. PERIARTERIOLAR LYMPHOID SHEATS (PALS) B cells T cells arteriole
  • 39.  
  • 40.  
  • 41. In Summary
    • Specialized tissues (secondary lymphoid organs) concentrate Ag
    • that were introduced through the physical barriers.
    • Naïve cells migrate through SLO, where they recognize Ag and
    • initiate an immune response.
    • Effector and memory lymphocytes circulate in the blood and to
    • SLO.

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