Organs Immune System 1

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Organs Immune System 1

  1. 1. THE ORGANS OF THE IMMUNE SYSTEM
  2. 3. Lymphocytes
  3. 5. Lymphocytes
  4. 6. SOURCE OF LYMPHOCYTES Fetus Primary Lymphoid Organs Secondary Lymphoid Organs Adult
  5. 7. SOURCE OF LYMPHOCYTES
  6. 9. SOURCE OF LYMPHOCYTES
  7. 10. HUMAN THYMUS
  8. 11. PRIMARY LYMPHOID ORGANS THYMUS (T cell maturation) (> lymphocytes) (< lymphocytes)
  9. 12. The functional thymus consists of two cell populations; the stromal cells and the thymocytes. The stromal cells include (1) the subcapsular epithelial cells; (2) the cortical epithelial cells; (3) the medullary epithelial cells; (4) macrophages; and (5) dendritic cells of bone marrow origin. (From Kierszenbaum AL: Histology and cell biology: an introduction to pathology, St Louis, 2002, Mosby.)
  10. 13. MHC-dependiente
  11. 14. Effects of Adult Thymectomy on Immune Response
  12. 15. CHICKEN THYMUS AND BURSA OF FABRICIUS
  13. 17. BURSA OF FABRICIUS (B cell maturation) follicle lumen Cortex (lymphocytes, M Ø, plasma cells) medulla
  14. 18. PEYER’S PATCHES Group I (90% Ileum ) Ruminants, Pigs, Horses, Dogs, Humans. Group II Illeum/Jejunum) Rabbits, Rodents.
  15. 19. When stimulated by antigen, immunoglobulin A (IgA)-producing B cells are produced in inductive sites, such as the Peyer’s patches.
  16. 20. The role of M cells as antigen-processing cells in the intestinal wall. Antigen that enters enterocytes is usually rapidly degraded in lysosomes. Antigen that enters M cells is not degraded. It may be presented directly to intraepithelial lymphocytes within the M. Yersinia, M. tuberculosis, Listeria, reovirus , Salmonella.
  17. 21. Structure of the two different types of Peyer’s patch (PP) in sheep. A, An ileal PP at age 8 weeks. B, A PP from the jejunum, also at 8 weeks. Original magnification ×32. (From Reynolds JD, Morris B: Eur J Immunol 13:631, 1983.)
  18. 22. SECONDARY LYMPHOID ORGANS LYMPH NODE
  19. 23. SECONDARY LYMPHOID ORGANS LYMPH NODE
  20. 24. (B cells) (stimulated) (T cells) (unstimulated) (B cells, macrophages, plasma cells) SECONDARY LYMPHOID ORGANS LYMPH NODE
  21. 25. SECONDARY LYMPHOID ORGANS LYMPH NODE secondary follicle primary follicle medulla subcapsular sinus dendritic cells
  22. 26. Circulation of Lymphocytes
  23. 28. HIGH ENDOTHELIAL VENULES
  24. 30. HIGH ENDOTHELIAL VENULES
  25. 32. HIGH ENDOTHELIAL VENULES
  26. 35. RP WP B cell follicle PLS Marginal Zone SPLEEN
  27. 37. SPLEEN
  28. 38. PERIARTERIOLAR LYMPHOID SHEATS (PALS) B cells T cells arteriole
  29. 41. In Summary <ul><li>Specialized tissues (secondary lymphoid organs) concentrate Ag </li></ul><ul><li>that were introduced through the physical barriers. </li></ul><ul><li>Naïve cells migrate through SLO, where they recognize Ag and </li></ul><ul><li>initiate an immune response. </li></ul><ul><li>Effector and memory lymphocytes circulate in the blood and to </li></ul><ul><li>SLO. </li></ul>

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