Your SlideShare is downloading. ×
0
Antigen  Processing
Antigen  Processing
Antigen  Processing
Antigen  Processing
Antigen  Processing
Antigen  Processing
Antigen  Processing
Antigen  Processing
Antigen  Processing
Antigen  Processing
Antigen  Processing
Antigen  Processing
Antigen  Processing
Antigen  Processing
Antigen  Processing
Antigen  Processing
Antigen  Processing
Antigen  Processing
Antigen  Processing
Antigen  Processing
Antigen  Processing
Antigen  Processing
Antigen  Processing
Antigen  Processing
Antigen  Processing
Antigen  Processing
Antigen  Processing
Antigen  Processing
Antigen  Processing
Antigen  Processing
Antigen  Processing
Upcoming SlideShare
Loading in...5
×

Thanks for flagging this SlideShare!

Oops! An error has occurred.

×
Saving this for later? Get the SlideShare app to save on your phone or tablet. Read anywhere, anytime – even offline.
Text the download link to your phone
Standard text messaging rates apply

Antigen Processing

521

Published on

Published in: Technology
0 Comments
0 Likes
Statistics
Notes
  • Be the first to comment

  • Be the first to like this

No Downloads
Views
Total Views
521
On Slideshare
0
From Embeds
0
Number of Embeds
0
Actions
Shares
0
Downloads
25
Comments
0
Likes
0
Embeds 0
No embeds

Report content
Flagged as inappropriate Flag as inappropriate
Flag as inappropriate

Select your reason for flagging this presentation as inappropriate.

Cancel
No notes for slide

Transcript

  • 1. DENDRITIC CELLS AND ANTIGEN PROCESSING
  • 2.  
  • 3.  
  • 4.  
  • 5. epitope
  • 6. adherence phagosome phagolysosome degradation excretion
  • 7. Endogenous peptides Exogenous peptides  1  2  3  2m  1  1  2  Tc CD 8 Citotoxicity Th CD 4 Humoral response Cellular response
  • 8.  
  • 9. EXOGENOUS ANTIGEN-PROCESSING CELLS Dendritic cell AntIgen B cell Macrophage Helper T cell CD 4
  • 10. The Origin of Dendritic Cells (DC) Epidermal DC Interstitial DC Only in mice
  • 11. DC LT LT
  • 12.  
  • 13. Skin 1 2 3 Dendritic Cells Veiled cells 4 MHC II 5 Dendritic cell 6
  • 14. IL-4, 5, 10 1 DC >> 3,000 LT B B B B T T T T T T T T
  • 15.  
  • 16. Dentritic Cells 1 and 2 IL-1, IL-4, IL-6
  • 17.  
  • 18. Antigen presentation by dendritic cells Antigen Dendritic cell Beading of dendrites Iccosomes Ag presentation IL-1, IL-12 Th cell B cell
  • 19. RER CITOPLASMA Membrana celular Procesamiento de Antígenos Exógenos fagosoma ESPACIO EXTRACELULAR
  • 20. RER MHC II CITOPLASMA Membrana celular Procesamiento de Antígenos Exógenos Ag parcialmente digerido (fagolisosoma) Compartimiento endocitico ESPACIO EXTRACELULAR mRNA
  • 21. Ii cadena invariante RER CITOPLASMA
  • 22. CITOPLASMA
  • 23. CLIP (class II-associated li peptide) CITOPLASMA DM
  • 24. RER Ag parcialmente digerido CITOPLASMA Membrana celular Procesamiento de Antígenos Exógenos ESPACIO EXTRACELULAR
  • 25. RER CITOPLASMA Membrana celular Procesamiento de Antígenos Exógenos ESPACIO EXTRACELULAR
  • 26. RER CITOPLASMA Membrana celular Expresión de Ag unido a MHC II Procesamiento de Antígenos Exógenos ESPACIO EXTRACELULAR
  • 27.  1  2  1  2 epitopo MHC II CPA (M Ø , LB, DC) Interacción MHC II-RCT y CD4         CD4 Célula Th CD4+ CD3 RCT
  • 28. Procesamiento de Ag Endógenos (1). TAP-1 TAP-2 Calnexina (chaperonina )  1  2  3  2m Proteasoma Ag Viral
  • 29. proteasoma ubiquitina U
  • 30. Complejo Péptido-MHC I Procesamiento de Ag Endógenos (2). RER Membrana celular ESPACIO EXTRACELULAR CITOPLASMA mRNA Viral MHC I mRNA MHC I con epitopo U Proteasoma TAP U U U biquitina U U U
  • 31.  1  2  3  2m Célula nucleada epitopo Interacción MHC I- RCT-CD8   RCT CD8 Célula Tc CD8+

×