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Antigen Processing

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  • 1. DENDRITIC CELLS AND ANTIGEN PROCESSING
  • 2.  
  • 3.  
  • 4.  
  • 5. epitope
  • 6. adherence phagosome phagolysosome degradation excretion
  • 7. Endogenous peptides Exogenous peptides  1  2  3  2m  1  1  2  Tc CD 8 Citotoxicity Th CD 4 Humoral response Cellular response
  • 8.  
  • 9. EXOGENOUS ANTIGEN-PROCESSING CELLS Dendritic cell AntIgen B cell Macrophage Helper T cell CD 4
  • 10. The Origin of Dendritic Cells (DC) Epidermal DC Interstitial DC Only in mice
  • 11. DC LT LT
  • 12.  
  • 13. Skin 1 2 3 Dendritic Cells Veiled cells 4 MHC II 5 Dendritic cell 6
  • 14. IL-4, 5, 10 1 DC >> 3,000 LT B B B B T T T T T T T T
  • 15.  
  • 16. Dentritic Cells 1 and 2 IL-1, IL-4, IL-6
  • 17.  
  • 18. Antigen presentation by dendritic cells Antigen Dendritic cell Beading of dendrites Iccosomes Ag presentation IL-1, IL-12 Th cell B cell
  • 19. RER CITOPLASMA Membrana celular Procesamiento de Antígenos Exógenos fagosoma ESPACIO EXTRACELULAR
  • 20. RER MHC II CITOPLASMA Membrana celular Procesamiento de Antígenos Exógenos Ag parcialmente digerido (fagolisosoma) Compartimiento endocitico ESPACIO EXTRACELULAR mRNA
  • 21. Ii cadena invariante RER CITOPLASMA
  • 22. CITOPLASMA
  • 23. CLIP (class II-associated li peptide) CITOPLASMA DM
  • 24. RER Ag parcialmente digerido CITOPLASMA Membrana celular Procesamiento de Antígenos Exógenos ESPACIO EXTRACELULAR
  • 25. RER CITOPLASMA Membrana celular Procesamiento de Antígenos Exógenos ESPACIO EXTRACELULAR
  • 26. RER CITOPLASMA Membrana celular Expresión de Ag unido a MHC II Procesamiento de Antígenos Exógenos ESPACIO EXTRACELULAR
  • 27.  1  2  1  2 epitopo MHC II CPA (M Ø , LB, DC) Interacción MHC II-RCT y CD4         CD4 Célula Th CD4+ CD3 RCT
  • 28. Procesamiento de Ag Endógenos (1). TAP-1 TAP-2 Calnexina (chaperonina )  1  2  3  2m Proteasoma Ag Viral
  • 29. proteasoma ubiquitina U
  • 30. Complejo Péptido-MHC I Procesamiento de Ag Endógenos (2). RER Membrana celular ESPACIO EXTRACELULAR CITOPLASMA mRNA Viral MHC I mRNA MHC I con epitopo U Proteasoma TAP U U U biquitina U U U
  • 31.  1  2  3  2m Célula nucleada epitopo Interacción MHC I- RCT-CD8   RCT CD8 Célula Tc CD8+

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