Skin Disorders - Dermatology MRCP 1 - 123Doc Education

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Skin Disorders, as part of the Dermatology MRCP 1 course. These are slideshows only. The demonstration with video presentation and explanation that goes along with these slides, as well as free example exam questions and the paid full e-lecture can be viewed at https://www.123doc.com/electures/dermatology/

Skin Disorders - Dermatology MRCP 1 - 123Doc Education

  1. 1. Dermatology Dr Katie Lacy
  2. 2. Blistering skin disorder • Bullous pemphigoid • Pemphigus vulgaris • Erythema multiforme / Steven Johnson syndrome / toxic epidermal necrosis • Porphyrias • Dermatitis herpetiformis
  3. 3. Bullous pemphigoid • Elderly • Tense, fluid filled blisters on erythematous background • Antibody mediated, auto immune disorder • Split at dermoepidermal junction • Treat with oral immunosuppression
  4. 4. Erythematous lesions
  5. 5. Bullous pemphigoid
  6. 6. Pemphigus vulgaris • Elderly • Eroded areas over body, oral involvement common • Intraepidermal split • Paraneoplastic association • Treat oral immunosuppression
  7. 7. Pemphigus vulgaris
  8. 8. Erythema multiforme • Hypersensitivity reaction • Usually triggered by infection or drugs • Targetoid skin lesion, many become bullous • Usually self limiting, but recurrent form • If mucous membranes involved known as Stevens-Johnsons Syndrome
  9. 9. Toxic Epidermal necrolysis • 80% due to drug reaction • Severe, >30% skin detachment with positive Nikolsky’s sign • Mucous membrane involvement in 90% • High mortality • Intravenous immunoglobulins may provide benefit
  10. 10. Erythema Multiforme
  11. 11. Erythema Multiforme
  12. 12. Toxic Erythema Necrosis
  13. 13. A 68 year-old woman presents with a 2 month history of a widespread pruritic rash. Examination reveals widespread erythema with several small blisters containing straw-colored fluid and one or two larger serosanguinous blister.
  14. 14. What is the most likely diagnosis?
  15. 15. What is the most likely diagnosis? A. Bullous impetigo B. Bullous pemphigoid C. Insect bite D. Scabies E. Urticarial vasculitis

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